The effects of IHC-72 on arrhythmia and lipid peroxides of ischemia and reperfusion rat hearts in vivo
- VernacularTitle:IHC-72抗大鼠缺血再灌注心律失常及脂质过氧化作用
- Author:
Guangju JI
;
Jingzhen ZHANG
;
Dehua ZHAO
- Publication Type:Journal Article
- Keywords:
IHC-72;
verapamil;
myocardial reperfusion in jury;
arrhythmia;
lipid peroxides
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Acute myocardial ischemia and reperfusion led to arrhythmias and increase of glutamic oxalacetic transaminase (GOT),lactate dehydrogenase (LDH),non-csterified fatty acid (FFA) and malondialdehyde (MDA) content, and decrease of superoxide dismutase (SOD) activity in rats. 3, 6-di-methylamino-dibenzopyri-odonium edetate (IHC-72) 5 mg?kg-1 iv significantly reduced the incidence of ventricular tachy-cardia (VT) and ventricular fibrillation(VF) ,shortened the duration of arrhythmias induced by reperfusion, decreased the release of GOT, LDH and FFA, obviously reduced the MDA content,and effectively protected SOD activity in ischemia-reperfused rat hearts. Our experimental results suggested that IHC-72 had protective effects on ischemia-reperfusion injury rat hearts in vivo. The mechanism of the protection might be associated with the inhibition of cellular lipid peroxidation.
