Study on the pharmacokinetics of alprazolam at different dose in rats
- VernacularTitle:不同剂量阿普唑仑在大鼠体内的药动学研究
- Author:
Yunsheng GAO
;
Yuyun ZHU
;
Junqing QU
- Publication Type:Journal Article
- Keywords:
alprazolam;
pharmacokinetics;
drug levels in serum;
re versed-phase HPLC
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The pharmacokinetics of alprazolam in 18 rats was studied by using reversed-phase HPLC. The pharmacokinetic characteristics were fit to one compartment opened model after intragastric administration of alprazolam at doses of 50,20 and 2 mg ? kg-1, respectively. The absorbing and eliminating parameters between the three groups were no significant difference. Mean of Ka was 3. 3454 h-1,Ke 0. 3873h-1,T1/2Ka 0. 29 h, T1/2Ke 2.61 h, and Tmax 1.04 h. There was a positiverelationship between the serum concentration and dosage (r = 0. 6096, P
