Effect of nifedipine on polymorphonuclear leukocytes oxygen metabolism in coronary heart disease
- VernacularTitle:硝苯吡啶对冠心病患者中性粒细胞氧自由基的影响
- Author:
Taiping WANG
;
Qin LI
;
Xuegong SHI
- Publication Type:Journal Article
- Keywords:
nifcdipine;
coronary heart disease ( CHD );
polymorphoriuclear leukocyte (PMN);
oxygen free radical (OFR)
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Luminol dependent chemilumi-nescence (CL) method was used to observe effect of nifedipine on polymorphonuclear leukocytes (PMN) oxygen metabolism in coronary heart disease (CHD). Studied subjects including 24 cases of coronary heart disease non using nifedipine, 26 cases of coronary heart disease using nifedipine group (10.mg tid on 3~7 days), 30 cases of normal drug-free subjects.The results showed that: 1. PMN-CL in using nifedipine CHD group was sigrlifficantly lower, its PMN- CL backgroud, peak value andphargocyte index was signifficantly lower than that in non using nifedipine CHD group. 2. PMN-CL peak value and phargocyte index in using nifedipine CHD group had no signifficantly differences compared with normal group. 3. Parameters of PMN- CL in non using nifedipine CHD group were signifficantly higher than that in normal group.
