CORRELATION OF EBV-DNA IN CANCER CELLS AND ANTIBODY OF SERUM EBV IN PATIENTS WITH NASOPHARYNGEAL CARCINOMA IN NORTHWEST CHINA
- VernacularTitle:西北地区鼻咽癌患者血清EB病毒抗体与癌细胞EBV-DNA的相关性
- Author:
Yanfang SUI
;
Huizhong ZHANG
;
Wenliang WANG
- Publication Type:Journal Article
- Keywords:
Nasopharyngeal carcinoma;
Epstein-Barr virus;
In situ hybridization;
Immunocytochemistry
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Assay"'of Epstein-Barr virus (EBV) DNA was conducted in the tissues of 60 patients with nasopharyngeal carcinoma (NPC), 30 patients with chronic inflamation of nasopharyngeal mucous membrane and 40 patients with other malignant epithelial tumor respectively using DNA in situ hybridization method. The positive rate of EBV-DNA in patients of NPC was 71.6%, while it was negative in pat ents with other malignant tumors a small number of EB-VDNA positive cells were also discovered in the epithelial cells of paratumours and chronic inflamation of nasopharyngeal mucous membrane. Significant correlation was found in the study of serum EBV-antiby in patients of NPC and EBV-DNA in cancer cells. The results suggest that EBV may be of etiologic significance in the pathogenesis of NPC.
