ORTHOTOPIC TRANSPLANT MODEL OF HUMAN PANCREATIC CANCER IN NUDE MICE AND THEIR BIOLOGICAL PROPERTIES
- VernacularTitle:两株人胰腺癌裸小鼠胰腺内原位移植模型的建立及其生物学特性
- Author:
Qiuzhen LIU
;
Chaowei TUO
;
Longshi ZHANG
;
Yanhua ZHANG
;
Detan TANG
- Publication Type:Journal Article
- Keywords:
Pancreatic cancer;
Nude mous;
Orthotopic transplant;
Invation;
Disease models
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Two cell strains from human pancreatic cancer taken surgically were transplanted to the pancreas of pureline BALB/C-nu/nu nude mice and 9 generations of PTNMP-1 and 6 generations of PTNMP-2 were obtained. Biological properties were studied. It yielded a transplant success rate of 95% - 100% and large amount of CEA. Analysis of the karyotype confermed that they retained the karyotype of human cancer cells. Some lymphatic and blood stream metastasis and invasion could be found in the nude mice orthotopically transplanted with tumour, showing that the transplanted tumour had characteristics identical with the donor tumour.
