Increased Interleukin-17 Expression in Patients with Idiopathic Inflammatory Myopathies.
10.4078/jkra.2008.15.2.118
- Author:
Seung Hoon BAEK
1
;
Jun Hee LEE
;
Geun Tae KIM
;
Joung Wook LEE
;
Mi Ra CHO
;
Ju In KIM
;
Sun Hee LEE
;
Dae Seong KIM
;
Sung Il KIM
Author Information
1. Department of Internal Medicine, College of Medicine, Pusan National University, Busan, Korea. ksimd@pusan.ac.kr
- Publication Type:Original Article
- Keywords:
Interleukin-17;
Idiopathic inflammatory myopathies;
Dermatomyositis;
Polymyositis
- From:The Journal of the Korean Rheumatism Association
2008;15(2):118-122
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: Idiopathic inflammatory myopathies (IIMs) are systemic autoimmune diseases characterized by infiltration of T lymphocytes, monocytes, and macrophages in muscle tissues. Interleukin-17 (IL-17), a Th17 cytokine, has potent pro-inflammatory actions and plays a role in autoimmune diseases. We investigated the expression of IL-17 in muscle tissues of patients with IIMs. METHODS: We measured the IL-17 mRNA level of muscle tissues from 14 patients with IIMs (9 patients with dermatomyositis and 5 patients with polymyositis) by real-time RT-PCR and compared with controls. We also performed an immunohistochemical stain to detect IL-17 expression. RESULTS: The expressions of IL-17 were significantly enhanced in IIMs than controls. In immunohistochemistry, IL-17 was expressed in perimysial, endomysial and perivascular infiltrating inflammatory cells. CONCLUSION: These results suggest that IL-17 plays a role in the immunopathogenesis of IIMs.
