Alterations of Myocardial Mitochondrial Function Subjected to Ischemia/Reperfusion Injury in Cats
- VernacularTitle:猫心肌缺血再灌注过程线粒体功能的变化
- Author:
Long CHEN
;
Baoren ZHANG
;
Jialin ZHU
;
Rukun CHEN
;
Jiahua HAO
;
Xiaoqin CHEN
;
Kerning CHEN
- Publication Type:Journal Article
- Keywords:
myocardial ischemia;
reperfusion injury;
cardiopulmonary bypass;
lipid peroxides;
superoxide dismutase;
extracorporeal circulation;
cats
- From:
Academic Journal of Second Military Medical University
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The effect of myocardium subjected to 60 min ischemia and 60 min reperfusion on the level of lipid peroxides (LPO) and function of myocardial mitochondria and activity of superoxide dismutase (SOD) was studied in cat cardiopulmonary bypass. Myocardial mitochondrial function was slightly depressed after 60 min ischemia but significantly depressed after 60 min reperfusion. Increased lipid peroxides content and decreased SOD activity were observed at 60 min ischemia. After reperfusion, the SOD activity continued decreasing, but LPO elevated apparently. These results support a hypothesis that the free radicals may contribute to the myocardial mitochondrial reperfusion injury.
