Effects of Picrotoxin Injection into Lateral Ventricle of the Cat on Cardiac Contractility and Renal Nerve Discharge .
- VernacularTitle:猫侧脑室注入印防已毒素对心肌收缩力及肾交感神经活动的影响
- Author:
Jun DAI
;
Jianguo CHEN
;
Gangxing HOU
;
Weijun YUAN
;
Weijun FU
- Publication Type:Journal Article
- Keywords:
GABA;
picrotoxin;
myocardial contraction;
cats
- From:
Academic Journal of Second Military Medical University
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The present study was undertaken to observe the effect of picrotoxin(PT) injection into lateral ventricle (LV) on cardiac contractility (CC) and renal nerve discharge (RND).lt was found that PT injection into LV caused CC and RND to increase significantly, and this effect was dose-dependent.The effect of baroreflex on cardiovascular response produced by PT injection was also observed. Data suggested that PT injection into LV still caused CC and RND to increase when the buffer nerve was sectioned. The magnitude of increase was significantly larger than that of the intact buffer nerve. The results indicate that in the CNS, the block of gamma-aminobutyric acid (GABA) transmitter system not only could cause blood pressure and heart rate to increase, but also strengthen CC and RND; baroreflex could partly suppress cardiovascular response caused by PT injection.
