The Effects of Recovery-Pulse Decoction of Colla corii asini (Ejiao) on Platelets, Blood Coagulation and Iipid Peroxidation in Rats with Endotoxemia
- VernacularTitle:阿胶复脉汤对大鼠内毒素血症血小板、血液凝固性与脂质过氧化变化的影响
- Author:
Yongshi WANG
;
Zhiquan FAN
- Publication Type:Journal Article
- Keywords:
endotoxemia;
lipid peroxidation;
platelet;
clloa corii asini (ejiao);
disease models, animal;
rats
- From:
Academic Journal of Second Military Medical University
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The endotoxemia model was established by intraabdominal injection of endotoxin Coli B. (E. Coli O55B5,8 mg/kg weight)in albino rats. Two hours before administration of endotoxin, the ejiao recovery-pulse decoction was perfused into the stomach tube of the rats in the experimental group (10mg/kg weight), and 12h later, the platelets were counted, kaolin activated partial thromboplastin time (KPTT), prothrombin time (PT) and thrombin time (TT) were measured, and malondialdehyed (MDA) levels in plasma and platelet were determined by thiobarituric acid (TBA) fluorometry. The results demonstrate that the ejiao recovery-pulse decoction could prevent from peripheral platelet dropping, KPTT and TT prolonging and MDA level rising which were caused by endotoxin.
