The effects of naloxone and positive end expiratory pressure ventilation on respiratory function in dogs with experimental RDS
- VernacularTitle:纳洛酮和呼气末正压通气对呼吸窘迫综合征犬呼吸功能的作用
- Author:
Jihong ZHOU
;
Peifang ZHU
;
Yuanguo ZHOU
- Publication Type:Journal Article
- Keywords:
wounds;
gunshot;
respiratory insufficiency tnaloxone;
positive pressure respiration
- From:Journal of Third Military Medical University
1984;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Respiratory distress syndrome was produced in dogs with the combination of oleic acid injection and gunshot wounding,and the therapeutic effects of naloxone(NAD and positive end expiratory pressure ventilation(PEEP)were assessed with the examinations of macropatholo-gy of the lungs,lung water ratio.respiratory rate(RR)and blood gas analysis.It was found that RR was rapidly and significantly increased tPaO2 decreased and Qs/Qt increased and there was severe pulmonary hemorrhage,edema and atelectasis in the controls after injury.NAL treatment could slightly alleviate the increase of RR and prevent the early of PaCO2,but it had no effects on the changes of PaO2,Qs/Qt and increase pulmonary hemorrhage,edema and atelectasis.PEEP could improve the decrease of PaO2 and the increase of Qs/Qt and prevent pulmonary atelectasis and alveolar edema from occurring,but it could not significantly stop the increase of lung water ratio.
