Effects of benzyltetrahydropalmatine on atria and trachea in guinea pig
- VernacularTitle:苄基四氢巴马汀及己吡氰胍对豚鼠气管及心肌的作用
- Author:
Zhiping LIU
- Publication Type:Journal Article
- Keywords:
berbines;
benzyltetrahy- dropalmatine;
pinacidil;
left atxia;
trachealis;
dose-response curve
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Pinacidil caused a concentration -dependent decrease in the force of contraction,but, benzyltetrahydropalmatine ( BTHP ) increased the contractile force in isolated guinea pig left atria. Both BTHP and pinacidil suppressed the adrenaline- induced left atria auto-maticity.In isolated guinea pig trachealis,BTHP(5, 50 ?mol ?L-1) caused an apparent leftward shift of acetylcholine(Ach)or histamine dose-response curves, augmenting response to low Ach or histamine concentrations without or slightly change the tissue maximum response to the spasmogen. By contraries,Pinacidil(50 ? mol?L-1)produced a rightward shifts in the concentration - effect curve of Ach or Kis and depressed the foot of thedose-response curves for Ach or His without modifying the maximum response.In the presence of pinacidil BTHP did not modify the responses to either Ach or histamine. indeed,the specific antagonism between pinacidil and BTHP suggests that BTHP interact with the same or closely related sites of actions as the K channel blocker.
