Inhibitory action of dl-tetrahydropalmatine on gastric acid secretion in vitro
- VernacularTitle:延胡索乙素对离体大鼠胃酸分泌的抑制作用
- Author:
Yu LI
;
Jianhua WANG
;
Shaoxian LAO
;
Weiwen CHEN
- Publication Type:Journal Article
- Keywords:
dl - tetrahydropalmatine;
his- tamine;
gastric acid secretion;
drug action;
parietal cell;
isolated stomach;
rat
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The action of dl - tetrahydropal-matine(dl-THP) was studied in two preparations in vitro : the isolated rat gastric mucosa and parietal cells, dl-THP was found to inhibit significantly basal acid formation by the gastric mucosa in a dose - response fashion. The effect was reversible, acid secretion returning to control levels 1. 5~2h after the preparation underwent a double wash, dl - THP also produced asignificant and dose - dependent inhibition of histamine - induced secretion in the gastric mucosa and parietal cells, shifted the histamine dose -response cuver to the right and suppressed the maximum acid production, with pD_2~1 values of 4. 72 and 4. 70, respectively.
