Effects of artesunate on the hepatic GSH content in normal and hepatotoxin-poisoned mice
- VernacularTitle:青蒿琥酯对正常及肝脏毒物中毒小鼠肝脏谷胱甘肽含量的影响
- Author:
Chongyang CHEN
;
Zunian TANG
;
Ronggan LIANG
- Publication Type:Journal Article
- Keywords:
attesunate;
acetaminophen;
yellow phosphorus;
red need giurathione
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
This study was undertaken to examine the possible effects of Artesunate(Art) on the hepatic reduced glutathione(GSH) content in normal and hepatotoxin - poisoned mice. It was demonstrated that Art given ip( 100mg?kg-1or 200mg?kg-1 ? 3)to mice had a signifcant protection against hepatic GSH deplection induced by acetaminophen and yellow phosphorus, andthat Art also caused a marked increase of the hepatic GSH content in fasting mice at the dose of 200mg ? kg-1. These results indicate that Art can help the liver detoxication of toxic metabolits in mice.
