The influence of anisodamine(654-2) on lipid peroxides and pulmonary surfactant content in rabbits with acute lung injury induced by oleic acid
- VernacularTitle:山莨菪碱对油酸致急性肺损伤家兔脂质过氧化物及肺表面活性物质含量的影响
- Author:
Youling JING
;
Qiu YANG
;
Lianyuan ZHANG
- Publication Type:Journal Article
- Keywords:
pulmonary surfactant;
lipid peroxide;
oleic acid
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
In the study we determined the content of malondialdehyde(MDA) , which is the metabolite of lipid peroxide(LPO) , in plasm and lung homogenate by thiobarbituric acid(TBA) colorimetry, and the content of phosphatidyl-choline(PC), which is the major functional composition of pulmonary surfactant (PS).and total phospholipid (TPL) by thin-layer chromatogra-phy and inorganic phosphorus quantitative analysis in rabbits with lung injury induced by oleic acid. The results showed that the MDA level wasincreased in plasm and lung homogenate; PC and TPL were decreased in lung homogenate. Administrating of 654-2 before and after (0. 5 h)lung injury could both inhibit the production LPO and prevent the decrease of PS. The findings suggest that the decrease of PS may be due to the increase of LPO and that G54-2 could modify the process.
