Progressive Multifocal Leukoencephalopathy in a Patient with Systemic Lupus Erythematosus.

Author: Hoon Young KO ¹ ; Jun Ki MIN ; Hye Kang KIM ; Hee Yeon LEE ; Yong Soo SHIM ; Jee Young KIM
Author Information

1. Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
Publication Type:Case Report
Keywords: Progressive multifocal leukoencephalopathy; JC virus; SLE
MeSH: Humans
From:The Journal of the Korean Rheumatism Association 2008;15(2):159-164
CountryRepublic of Korea
Language:Korean
Abstract: Progressive multifocal leukoencephalopathy (PML) is a rare, serious, and usually fatal demyelinating disease that occurs predominantly in severely immunosuppressed patients. The disease is caused by the infection of oligodendrocytes with JC virus that is widely distributed as a latent infection in the general populations. PML has been described mainly in patients infected with the human immunodeficiency virus. However, other immune-suppressed patients including malignancies and organ transplants can be affected with JC virus infection. Recently it is suggested that rheumatologic diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis, dermatomyositis, polymyositis, wegener`s granulomatosis be known to be at risk of developing PML. We report a case of PML in a patient with SLE.