Cutaneous Leg Ulcer Mimicking Pyoderma Gangrenosum in Patient with Secondary Antiphospholipid Syndrome.
10.4078/jkra.2008.15.2.165
- Author:
Ki Hoon HUR
1
;
Seung Ki KWOK
;
Yoon Jung PARK
;
Jin Jung CHOI
;
Chul Soo CHO
Author Information
1. Division of Rheumatology, St. Mary's Hospital, School of Medicine, The Catholic University of Korea, Division of Rheumatology, Seoul, Korea. chocs@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Cutaneous ulceration;
Antiphospholipid syndrome;
Pyoderma gangrenosum;
Systemic lupus erythematosus
- MeSH:
Biopsy
- From:The Journal of the Korean Rheumatism Association
2008;15(2):165-169
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Antiphospholipid syndrome(APS) is characterized by vascular thrombosis in association with elevated titers of antiphospholipid antibodies. Leg ulcers are a considered to be a cutaneous manifestation of APS due to thrombosis of small to medium sized vessels. We report a case of necrotic non-healing, ankle ulcers mimicking pyoderma gangrenosum associated with APS in 50-year-old man. He had a past history of autoimmune thrombocytopenia and cerebral infarction. Laboratory findings showed a circulating lupus anticoagulant, positive anticardiolipin antibodies as well as anti-dsDNA and anti-Sm antibodies. Skin biopsy of ulcer lesions showed thrombotic vasculopathy of medium sized vessels with minimal leukocyte infiltration. Ulcers were successfully treated with surgical debridement and subsequent skin graft along with anticoagulation therapy.
