Effect of Arginine Vasopression on the Contents of cAMP and cGMP in the Cardiac Muscle in Vitro
- VernacularTitle:加压素对离体心肌cAMP和cGMP含量的影响
- Author:
Kang SUN
;
Chenghai WANG
;
Henian ZHU
- Publication Type:Journal Article
- Keywords:
vasopressin;
cardiac muscle;
negative inotropic effect;
cAMP;
cGMP
- From:
Academic Journal of Second Military Medical University
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The effect of arginine vasopressin (AW) on the contents of cAMP and cGMP in the isolated right atria and ventricular muscle strips was observed at the concentration possessing negative inotropic effect on the cardiac muscle (0.8ng/ml). Results showed that although there were accumulation of both cAMP and cGMP stimulated by AVP in the cardiac muscle, the increase of cGMP was more pronounced with the rise of cGMP/cAMP ratio from the control value 024 (atria) and 0.29(ventricle) to 0.45 and 0.41 respectively after treatment with AVP. Coupled with the known effect of cGMP in mediating the negative inotropic effect in the heart, cGMP is also a possible mediator of the negative inotropic effect of AVP in the heart. The significance of increase in cAMP stimulated by AVP awaits further studies.
