Value on Clinical Application of Citric Acid Extracted Protein Antigen from Human Skeletal Muscle to Detect the Thymoma-associated Antibody
- VernacularTitle:用柠檬酸提取人类骨胳肌蛋白抗原检测胸腺瘤相关抗体的临床应用价值
- Author:
Laihui TU
;
Renqin ZHANG
;
Deren HUANG
;
Hang LIN
- Publication Type:Journal Article
- Keywords:
myasthenia gravis;
thymoma;
CAE;
CAE-Ab;
patiento
- From:
Academic Journal of Second Military Medical University
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Thymus has an important significance to the pathogenesis and treatment for myasthenia gravis (MG). Thymoma accounts for 10 to 15% in the MG patients, which is short of localized damage feature so as to make misdiagnosis usually. Using citric acid extracted sacrolemma protein antigen from human skeletal muscle, CAE-Abs in the sera of 103 MG patients were detected by indirect hemoagglutination assay (IHA) and the positive rate was 78.9% (cases of 15/19); and then the CAE-Abs in the sera of 123 MG patients were detected by ELISA and the positive rate'was 82.6% (cases of 19/23). But the positive rate of CAE-Ab in the sera of MG without thymoma was only 0-4.0% (cases of 3/77). This results indicate that CAE-Ab has significant correlativity for MG with thymoma.
