Efficacy of Mebendazole Composite Cream in Treatment of Trichiniasis in Mice by Skin Administration
- VernacularTitle:复方甲苯咪唑乳膏涂肤剂对小鼠旋毛虫病的疗效
- Author:
Rongxing LIU
;
Yutang LI
- Publication Type:Journal Article
- Keywords:
mebendazole composite cream;
trichiniasis;
adult stage;
invasive larvae stage;
encysted larvae stage;
mice
- From:
Academic Journal of Second Military Medical University
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Male mice weighting 25-32g were infected with larvae of Trichinella spiralis. Skin administrations of mebendazole composite cream were carried out on the mice in 3 different experiment groups. It was found that there were the reduction rate of worms at 97.3%, 100% and 99. 7% in the adult worm group (50 mg/kg x 1 d), in the invasive larvae group (25 mg/kg x 7 d) and in the encysted larvae group (25 mg/kg x 7 d), respectively. These results indicate that mebendazole composite cream is very effective against both intestinal and muscular phases of T. spiralis.
