Effects of acute hypercapnia and cedilanid on diaphragmatic functions in dogs
- VernacularTitle:急性CO_2潴留及西地兰对犬膈肌作用观察
- Author:
Xianjian GUO
;
Wancheng DONG
;
Donglin WANG
- Publication Type:Journal Article
- Keywords:
diaphragmatic;
transdiaphragmatic pressure;
diaphragmatic electromyogram;
hy-percapnia;
lanatosides
- From:Journal of Third Military Medical University
1988;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
After electrical stimulation of the phrenic nerve,the function of the diaphragm was assessed by measurement of the transdiaphragmatic pressure (PDi),establishment of the Pdi-sti-mulating frequency (F) curve,and analysis of the power spectrum on the diaphragmatic elec-tromyogram (EMGdi) at spontaneous breathing.Hypercapnia of the dogs was induced by forcing the animals to inhale a mixture of CO2 and air.The findings were as follows:(1) After acute hypercapnia,PDi rapidly and progressively decreased.The power spectrum of EMGdi was also reduced.The PDi-F curve was shifted to right.These findings suggest that the function of the diaphragm was severely damaged.(2) The decrease of pH value was the important cause of diaphragmatic fatigue.(3) The diaphragm in a static condition could reduce the damage of hypercapnia.(4) Cedi-lanid exerted certain effects on the prevention of diaphragmatic fatigue created by acute hypercapnia.
