Prevention of terbutaline-induced down-regulation of betaadrenoceptors in lymphocytes with ketotifen in asthmatic guinea-pigs
- VernacularTitle:哮喘豚鼠淋巴细胞?-受体下调及酮替芬预防作用的实验研究
- Author:
Kefang LAI
;
Peiji LING
;
Pingfang SONG
- Publication Type:Journal Article
- Keywords:
asthma;
receptors;
adrenergic;
beta;
ketotifen;
terbutaline
- From:Journal of Third Military Medical University
1988;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
An experimental model of asthma was established with ovalbumin sensitization in guinea-pigs and then the preventive effects of ketotifen on the terbutaline-induced down regulation of beta-adrenoceptors in lymphocytes were investigated with radioligand binding assay.It was found that terbutaline significantly reduced the density of beta-adrenoceptors in lymphocytes,ketotifen administered simultaneously with terbutaline prevented the density of beta-adrenoceptors in lymphocytes from reducing.and neither ketotifen nor terbutaline changed the Kd values in either group.These findings suggest that ketotifen is of value to provent asthmatic patients from the adverse effects of tschyphylactic therapy of beta-adrenoceptor stimulants.
