The effect of aminophylline to strenthen diaphragmatic function in dogs
- VernacularTitle:氨茶碱增强犬膈肌功能作用
- Author:
Dongling WANG
;
Wancheng DONG
;
Xianjian GUO
- Publication Type:Journal Article
- Keywords:
aminophylline;
diaphragm Itransdiaphragmatic pressure;
electromyography
- From:Journal of Third Military Medical University
1988;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
After the bilateral phrenic nerves of the dogs were stimulated,the effect of amino-phylline on the function of normal and fatigued diaphragm was observed with the determination of transdiaphragmatic pressure-stmulation frequency curve (Pdi-F).and the analysis of the power spectrum of diaphragmatic electromyogram (DMGdi) at spontaneous breathing.After the administration of 10 and 20 mg/kg of aminophylline ,the PDi pf the normal diaphragm was increased and that of the fatigued diaphragm recovered.The Pdi-F curve of the fatigued diaphragm was shifted to the left,and the central frequency,the medium frequency,and the high/low frequency ratio were markedly increased.It is concluded that aminophylline at the therapeutic dosage can imporve the generation of the strength and enhance the recovery of the fatigued diaphragm.
