The effects of tetrandrine on metabolism of prostaglandin and lipids in patients with essential hypertension
- VernacularTitle:粉防己碱对原发性高血压患者前列腺素和脂质代谢的影响
- Author:
Shuyuan CHEN
;
Songbai YE
- Publication Type:Journal Article
- Keywords:
tetrandrine;
essential hypertension;
apoB_(100);
apoA_1;
prostaglandins;
h-pidic peroxidation
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of tetrandrine on serum TXB2, 6 - Keto - PGF1?, LPO and lipids in patients(n= 40)with essential hypertension has been studied. The results showed that: (1) The levels of serum 6 - Keto -PGF1?,apoA1 in EHT were lower and the level of serum TXB2,LPO and apoB100 were higher than those in control. (2)Patients with essential hypertension treated with tetrandrine (0.1 ~ 0. 2g,tid,po)for 3 mon revealed that thelevels of TXB2, LPO and apoB100 were decreased, and the levels of apoA1 and 6 - Keto - PGF1? were increased. In conslusion,tetrandrine stimulated the synthesis of PGI2 and inhibited the release of TXA2 and normalized the metabolism of lipids in patients with essential hypertension.
