Antiarrhythmic effects of 13 - n - Propyl-Palmatine
- VernacularTitle:13-正丙基巴马汀的抗心律失常作用
- Author:
Shuyi ZHAO
- Publication Type:Journal Article
- Keywords:
ouabain;
aconitine;
BaCL_2;
CaCL_2;
chloroform;
Na~+, K~+ -ATPase
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Intravenous injection of 13-n-Propyl-Palmatine 8 mg ? kg-1 reduced markedly the incidence of VF induced by chlorofom in the mice,elevated the threshold doses of Ouabain induced VP,VT,VF,CA in guinea pigs. Iv 1, 3mg ? kg-1 reduced signifi- cantly the incidence of arrhythmia induced by CaCl2 in the mice,shortened the total duration of arrhythmia induced by BaCl3 in therats. However, it was not so effective on A-conitine - induced arrhythmia in the rats. In addition, 13 - n - Propyl - Palmatine elevated significantly the activities of Na+, K+ - AT-Pase in the myocardial cellular membranes of rats.
