The studies on pharmacokinetics of Quercetin in rabbits.
- VernacularTitle:槲皮素在兔体内的药代动力学
- Author:
Weizhong ZHAO
;
Liming DEI
;
Chuangeng MA
- Publication Type:Journal Article
- Keywords:
Quercetin;
UV - spec-trophotometriy;
pharmacokinetics
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The studies on pharmacoki-netics of Quercetin in rabbits were carried out by UV-spectrophotometry. The experimental results were shown that after 10mg ? kg-1 of Quercetin iv administration in rabbits, the curve of plasma concentration - time was shown to fit an open two compartment model. The pharmacokinetic parameters were as follow:T1/2 (?) = 2. 91 ? 1. 36min,T1/2(?) = 183. 78?82. 67min,Vd=0. 624?0. 225L ???kg-1,CL = 3. 15 ?2. llml ? kg-1 ? min-1. The bioavailability (F) of Quercetin after 10mg ? kg-1 ig in rabbits was 42.7% and Cpk was 10. 9mg ? L, tpk was 60min.After 10mg ? kg-1 iv administration in rabbits,Quercetin was rapidly eliminated from the blood. The compound and its metabolites were exereten by kidney and bile.
