Protective effects of bepridil on experimental myocardial ischemia
- VernacularTitle:苄普地尔对实验性心肌缺血的保护作用
- Author:
Jinming CHEN
;
Shuling GU
;
Zhenyu PENG
- Publication Type:Journal Article
- Keywords:
bepridil;
propranolol;
myocardial ischemia;
myocardial infarction;
rabbits;
rats
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Bepridil hydrochloride(Bep) hydrochloride is a new , long - acting antianginal and antiarrhythmic agent. Through the observation of ∑ST.NST.and NQ of ECG or nitro blue tetrazolium chloride staining, we studied the effect of Bep on liga-tion of the left coronary artery in rabbits and the myocardial ischemia induced by isopre-naline in rats. The results showed that in the groups treated with Hep andpropranolol theisoelectric level was facilitated. ∑ST.NST, NQ, thecreatine phosphokinase values and the weight percentage of infarcted myocardium were decreased. The myocardial ischemic injury was decreased by histopathological stud-
