The Effects of rhIL-3, rhIFN-r and DMSO on Proliferation and Differentiation of the HL-60 Cell Line in Vitro
- VernacularTitle:rhIL-3、rhIFN-?、DMSO单用或合用对HL-60细胞的增殖与分化的影响
- Author:
Rujun YANG
;
Minghua ZHANG
;
Feng YAN
- Publication Type:Journal Article
- Keywords:
HL-60 cells;
dimethyl sulfoxide;
gama-interferon;
interleukins
- From:
Academic Journal of Second Military Medical University
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
In this experiment, we studied the effects of rhIL-3, rhlFN-r and DMSO on the growth and differentiation of the human leukemia cell line HL-60. The results showed that three agents were capable of suppressing the proliferation of the HL-60 cells and inducing terminal differentiation of the cells, with the exception of early augmentation of the cell growth by the rhIL-3. The differentiation effect was most obvious in DMSO treated cells, then in rhIL-3 and least in rhIFN-r The enhanced effects occurred when the HL-60 cells were treated in combination with DMSO and rhIL-3 or rhIFN-r
