A study on the labeling of melanocytic tumors and nevi with anti-human proliferative cell antibody Ki-67
- VernacularTitle:黑素细胞肿瘤抗人增殖细胞抗体Ki-67标染研究
- Author:
Tianwen GAN
;
Rongqing LIU
;
Qingyi YE
- Publication Type:Journal Article
- Keywords:
melanoma;
melanocytic nevus;
Ki-67
- From:Journal of Third Military Medical University
1988;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Fifteen cases of malignant melanoma,17 cases of acquired nevus,18 cases of congenital small nevus,and 3 cases of congenital giant nevus were labeled with anti-human prolifera-tive cell antibody Ki-67 with ABC labeling method.It was found that 13 out of the 15 cases of malignant melanoma were positive and the positive rate of the tumor cells was ranged between 2% to 33%.After culture,the positive rate of the melanoma cells was 88%.But all the 3.types of melanocytic nevi were negative.The findings suggest that the labeling of anti-human proliferative cell antibody Ki-67 is a sensitive and specific method to identify melanocytic tumors and it is not sensitive enough to differentiate the minor changes of the 3 types of nevi.
