Effects of bepridil, nimodipine and nicardipine on the activity of CaM dependent protein kinase Ⅱ from mouse cerebrum in vitro
- VernacularTitle:苄丙咯、尼莫地平和尼卡地平对小鼠脑钙调蛋白依赖性蛋白激酶Ⅱ活力的影响
- Author:
Fangming TANG
;
Guangyi ZHANG
- Publication Type:Journal Article
- Keywords:
bepridil: nimodipine;
nicardipine;
CaM -dependent;
protein ki-naseⅡ
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of bepridil, ni-modipine and nicardipine on the activity of CaM - dependent protein kinase Ⅱ from mouse cerebrum were studied in vitro. Tt was found that bepridil significantly inhibitied the activity of CaM - PK Ⅱ with an IC50 value of 0. 3 mmol ? L-1. but nimodipine and nicardipine did not basi-cally influence the activity of the enzyme. The experimental results showed that the inhibitory effect of bepridil on the activity of CaM - PK Ⅱ was an antagonistic action of bepridil to CaM.
