Effects of Acute Brain Injury on the Contents of Neurotensin in Brain Areas, Pituitary Gland and Plasma in Rats
- VernacularTitle:急性颅脑伤对大鼠脑区、垂体和血浆中神经降压肽含量的影响
- Author:
Zhimin LIU
;
Baocheng LIN
;
Chenghai WANG
;
Changlin LU
;
Xiaolin ZHAO
- Publication Type:Journal Article
- Keywords:
neurotensin;
radioimmunoassay;
acute brain injury;
animals;
rat
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The changes of immunoreactive neurotensin (ir-NT) contents in the brain areas, pituitary gland and plasma in the trautized rats were observed by radioimmunoassay. The results showed the significant changes of the ir-NT contents in the hypothalamus, pituitary gland, plasma, injured tissue, hippocampus, central gray and spinal cord in the posttraumatic rats at different intervals. A predominant characterization of the change of ir-NT levels in the brain areas, pituitary gland and plasma, was the dramatical decrease at various times except for the hypothalamus, central gray, and hippocampus with biphasic alterations. The ir-NT contents in the frontal cortex, pons and medulla also displayed changes to different extent under the acute craniocerebral trauma condition These results suggest that NT may play a role in the pathophysiology of traumatic injury.
