Ihe Effect of Arginine Vasopressin on Acute Ischeme Brain Edema and Its Mechanism
- VernacularTitle:精氨酸加压素对急性缺血性脑水肿的作用及其机理
- Author:
Xinfeng LIU
;
Yinmian SHI
;
Baocheng LIN
;
Chenghai WANG
- Publication Type:Journal Article
- Keywords:
ischemic brain edema;
arginine vasopressin Na+ -K+ATPase;
second messenger systems;
monoglian gerbils
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The purpose of this experiment was to study the role of arginine vasopressin (AW) in acute cerebral ischemic edema in mongolian gerbils. The results showed that intracerebroventricular injection (ICV) of AVP exacerbated the ischemic brain edema, while ICV of AW antiserum significantly decreased the ischemic brain edema. Nimodipine couldn't block this role of AW in ischemic brain edema. The cortical Na+ -K+ ATPase activity was significantly decreased, the contents of cAMP in the ischemic cortex and hypothalamus and the contents of cGMP in the hypothalamus were remarkably increased after ICV of AW. These suggest AW was involved in the pathophysiologic process of acute ischemic brain edema. And its mechanism might be the effect of AW on AW receptor mediated by cAMP, cGMP, and that in turn inhibited the Na+ -K+ ATPase activity of brain cell membrane, then exaggerated the formation of ischemic brain edema.
