Glucocorticoid-induced DNA Fragmentation in CEM-C7 Gells
- VernacularTitle:糖皮质激素对CEM-C7细胞DNA的断裂作用
- Author:
Liangnian SONG
- Publication Type:Journal Article
- Keywords:
glucocorticoids;
leukemia, lymphoid;
programmed cell death;
deoxyribonudeic add
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Glucocorticoid could significantly inhibit the growth of a human acute leukimia cell line (CEM-C7) in dose- and time-dependent manners. Qucocorticoid had also cytotoxic effect on CEM-C7 cells which was reflected in inducing DNA fragmentation preceding cell death. Glucocorticoid -induced CEM-C7 cell killing belongs to programmed cell death, which could be reversed by RU486, a potent glucocorticoid receptor antagonist These results demonstrated that the effects of glucocorticoids on lymphocytosis were mediated by glucocortioid receptor, and that the programmed cell death induced by glucocorticoids might be the molecular basis of the therapeutic effects of glucocorticoids in the treatment of acute lymphoblastic leukemia
