Antiarrhythmia effects of bepridll
- VernacularTitle:苄普地尔抗心律失常作用
- Author:
Shuling GU
;
Jinming CHEN
;
Jayong GUI
;
Zhenyun PENG
- Publication Type:Journal Article
- Keywords:
Bepridil;
A conitine;
Ouabain;
Bad_2;
CaCl_2;
Adrenaline;
Reperfusion;
Anhythmia
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Bepridil (10mg ? kg-1) iv elevated the threshold dose of ouabain (15ug ? min-1 iv) in guinea-pig and aconitine (10?g ? kg-1 ? min-1 iv) in rat induced ventricular extrasystole, ventricular tachycardia, ventricular fibrillation and cardiac arrest. It shortened the duration of arrhythmia elicitde by Adr (50ug ? Kg-1 iv) in conscious rabbits and by BaCl2 (3mg ? kg-1 iv) in rats. It is also effective in preventing reperfusion-induced arrhythmias in aneasthetized rats.
