The inhibitory effects of sinomeuine on complement - induced shape change and degranulation in rat neutrophils
- VernacularTitle:青藤碱对补体激活的中性粒细胞形态学改变和脱颗粒的抑制作用
- Author:
Jinzheng WANG
;
Lijuan JIN
- Publication Type:Journal Article
- Keywords:
Polymorphonuclear neutrophilic leukocyte;
Rat;
Lysosome enzymes;
Sinomeuine
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Complement activation induces polymorphonucleal neutrophilic leukocyte (PMN) aggregation in circulation causing microvascular occlusion. The activated PMNs release lysosome enzymes which damage the tissue. It might take an important part in shock and multiple organ failure. We pre-treated rat PMNs with sinomeuine, which was extracted and purified from the stem of Sinomeuium acufum Rehd et Wils. It was found to inhibit the morphological changes and lysosome enzymes release in PMNs activated with zymosanactivated plasma. With administration of sinomeuine PMNs remained a spherical shape, no apparent ruffling or cytoplasmic projection and less aggregation. Elastase and Nacetyl-?-D-glucosaminidase content in PMNs supernatant increased less.
