Influences of Lyciun Barbarian Polysaccharide, Astragalus Polysaccharide, Polysaccharide of Acanthopanax Senticosus and Polysaccharide of Lipopolysaccharide on the Induction of LAK Cells in vitro
- VernacularTitle:枸杞子多糖、黄芪多糖、刺五加多糖和鼠伤寒杆菌内毒素多糖对LAK活性的调节作用
- Author:
Guangwen CAO
;
Ping DU
;
Binghua JIAO
;
Hangmin THEN
- Publication Type:Journal Article
- Keywords:
polysaccharides;
polysaccharides, bacterial;
killer cells;
iodine radioisotopes;
in vitro
- From:
Academic Journal of Second Military Medical University
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Effects of Lycium barbarian polysaccharide (LBP), Astragalus polysaccharide (APS), polysaccharide of Acanthopanax senticosus (PAS) and polysaccharide of lipopolysaccharide (PS) on cytotoxicities of LAK cells from splenocytes of C57BL/6 mices were observed with 18 h 125IUdR release assay. Our study demonstrated that the polysaccharides alone were shown to induce no cytotoxicities. When combined with rIL-2, all of 4 kinds of the polysaccharides augrnented LAK activities in dose-dependent manner. The augmentations reached the maximum at 0.01-0.1 mg ? ml-1 LBP, 0.01 mg ? ml-1 APS and PAS, 0.01 mg ? ml-1 PS. They were found to increase LAK activities in short range of rIL-2 concentrations (250-1000U? ml-1). If the polysaccharides were used beyond the suitable concentrations, they were shown to inhibit LAK cell activities.
