Regulatory Action of Astragalus Saponins and Buzhong Yiqi Compound on Synthesis of Nicotinic Acetylcholine Receptor Antibody in Vitro for Myasthenia Gravis
- VernacularTitle:黄芪皂甙及补中益气复方对重症肌无力体外合成烟碱型乙酰胆碱受体抗体的调节作用
- Author:
Lalhui TU
;
Deren HUANG
;
Renqin ZTIANG
;
Qian SHEN
;
Youyu YU
;
Yongju HONG
;
Genghe LI
- Publication Type:Journal Article
- Keywords:
Astragalus membranaceus, saponins;
myasthenia gravis;
receptors, eholinergic;
medicine, Chinese traditional;
human
- From:
Academic Journal of Second Military Medical University
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
According to the differentiation of symptamcomplex theory of Spleen Deficiency on myasthenia grvis, with our clinical experience of treatment for some years. Astragalus Saponins and Buzhong Yiqi compound were selected to make phannaceutic experiment for peripheral blood mononuclear cells culture of 14 samples of 10 myasthenia gravis patients. Two controlled groups were given with the treatment of dexamethasone and 60Co respectively. The results showed that liters of nAchR-Ab in cells culture superatants were significantly decreased by watersoluble Astragalus saponias (418.8-2328 fmol/rnl- 0 fmol/ml in 6 cases; 1143 -1235 fmol/ml - 43-157 fmol/ml in 2 cases). Buzhong Yiqi compund could enhance the immunoregulatory action.
