The influence of hydrocholoride berbamine to the indothelium derived blood vessel relaxation induced by Acetylcholine
- VernacularTitle:盐酸小檗碱胺对乙酰胆碱引起的内皮依赖性血管舒张的影响
- Author:
Zhihui ZHONG
- Publication Type:Journal Article
- Keywords:
hydrocholoride berbamine ( HBA );
acetylcholine ( Ach );
verapamie (ver);
aorta;
endothelium
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
In the Ca - free solution .the relaxation induced by acctylcholine ( Ach ) inthe rabbit aortic strips is inhibited and the inhibition is removed when the concentration of the Ca2+ is restored. In the groupe of ME ( norepinephrine ) 0.4 ?mol ? L-1 hydro-choloride berbamine (HBA ) 1, 10?mol ? L-1 and Verapamie (Ver) 0. 1, 1?mol ? L-1 did not inhibit the relaxation induced by Ach,and HBA has tendency of promoting the relaxation. While HBA 100?mol ? L-1 and Ver 10?mol ? L-1 inhibit the relaxation obviously. In the group of KCl,the three concentration of HBA and Ver all have the tendency of promoting the relaxation. The result suggest: thatthe effection of HBA to the relaxation of in-dothelium dependence is complicated, the higher concentration inhibit the relaxation and the lower promote it. It prove that the effection of HBA to the transportation of indothelium's Ca2+ or to the release of the EDRF is complicated
