Elects of CI-930 plus PGE,or SQ-22536 on Arachidonic Acid Metabolism and cAMP Con-tents in Platelets
- VernacularTitle:CI-930与PGE_1或与SQ-22536合用对血小板AA代谢及cAMP含量的影响
- Author:
Huawu ZENG
;
Ximheng CHEN
;
Yuanying JING
;
Kun LONG
- Publication Type:Journal Article
- Keywords:
phosphodiesterdse inhibitors;
arachidonic arid;
adenosine cyclic monophosphate;
thromboxane A2;
prostaglandins
- From:
Academic Journal of Second Military Medical University
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The contents of cAMP and (14C)-AA metabolites in rabbit platelets were measured with RIA and radioactive TLC, respectively. PGE, could cooperate with the effect of CI-930. on platelets to increase the cAMP contents. It had no influence on the effect of CI-930 on metabolites of (14C)-AA, at the same time. SQ-22536 100?mol?L-1 could not chang the effect of CI-930 on platelets, which increase cAMP contents and affect AA metabolism. The date suggest that there is not relation between the effect of CI-930 on AA metabolism and on the cAMP contents in platelets.
