Prophylactic Effect of Magnesium Sulfate on Reperfusion Induced Arrhythmias in the Isolated Rat Hearts
- VernacularTitle:硫酸镁对离体大鼠心脏再灌流心律失常的预防作用
- Author:
Zuo HUANG
;
Scong CHEN
;
Guoyuan ZHANG
- Publication Type:Journal Article
- Keywords:
magnesium sulfate;
arrhythmias;
calcium;
anti-arrhythmia;
myocardial reperfusion;
myocardial reperfusion injury, animal;
rats
- From:
Academic Journal of Second Military Medical University
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Prophylactic effect of magnesium sulfate on reperfusion-airhythmias was studied using a left anterior descending coronary artery occlusion followed by reperfusion in the isolated rat hearts. In the first part of the present work, we observed a bell-shaped relationship between the incidence of reperfusion-induced ventricular fibrillation (VF) and the duration of preceding ischemia. In the second part, the concentration of magnesium sulfate in perfusate was increased to 3.6, 4.8 and 6.0mmol/L, respectively, 1 min before coronary ligation, VF fell in a dose-dependent manner from its control total incidence of 100% to 82%, 73% and 18% (P
