Blocking action of 1 -(? -naphthylmethyl) -2 -methyl- 6, 7 - dimethoxy- 1,2,3,4 -tetrahydroisoquinoline (86040) on ?-adrenoceptors
- VernacularTitle:1-(?-萘甲基)2-甲基-6,7-二甲氧基-四氢异喹啉对大鼠?-肾上腺素受体的阻断作用
- Author:
Guoqing LIU
;
Bangyuan HAN
;
Enhui WANG
;
Yuping CAO
- Publication Type:Journal Article
- Keywords:
tetrahydroisoquinoline 86040;
adrenoceptor;
vas deferens;
anococcygeus muscle
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The blocking action and selectivity of 1 - (? -naphthylmethyl)-2 - methyl - 6,7 - dimethoxy -1,2,3,4 -tetrahydroisoquinoline (86040) on a - a-drenoceptor have been investigated in isolated tissues. 86040 suppressed the inhibition of clonidine for the electrically stimulated twitch response of rat vas deferens ( - adre - noceptor), with pA2 value of 5. 85. 86040 could competitively inhibit anococcygeus muscle contraction (?1 -a-drenoceptor ) induced by phenylephrine with pA2 value of 7. 62. 86040 was found that the selectivity radio to block ?2 - and ?2 adrenoceptor(?1/?2)was 60. these results indicate that 86040 is a potentant relatively selective ?1 - adrenoceptor blocker.
