The study about the mechanism of antidepressant effect of 7903
- VernacularTitle:3,4-二氯苯丙烯酰另丁胺抗抑郁机制研究
- Author:
Shuxin LI
;
Baoshan KU
;
Haiyan YAO
- Publication Type:Journal Article
- Keywords:
antidepressants;
analogue of piperine;
turnover of monoamine;
radio ligand binding assay
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The influences of the N -Isosuccinyl - dichloro - cinnamoylamide (7903) on the NA and 5 -HT systems in the brain were studied. Acute administration of 7903 could significantly enhance the level of NA and 5 -HT in mice brain and cortex of rats, and the level of 5 -HT in the hyporthalamus of rats was tending to be enhanced. However, chronic administration of 7903 (two weeks ) could decrease the level of NA and the ra-tio of 5-HIAA/5-HT in the cortex of rats; Chronic administration of 7903 could also decrease the turnover of NA and 5- HT in mice brain, but had no effects on the special binding of ? - receptor to 3-H - DHA and that of 5 -HT receptor to H - ketanserine in the cortex of rats.
