A study on ginsenosides promoting immune function of rat splenocytes via hippocampus
- VernacularTitle:人参皂甙通过海马增强大鼠脾脏免疫功能的研究
- Author:
Ruiqiong WU
- Publication Type:Journal Article
- Keywords:
ginsenosides;
hippocampus;
IL - 2;
NK cell;
lymphocyte proliferation
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Enhancing effect of gin-senosides (GS) on immune function indirectly via hippocampus (HC was studied in this paper. The main results indicated that after the injection of GS into bilateral HC of rat directly by implantation at the dose of 5?10~8 kg per day for 4 days, splenocyte proliferative response to ConA was enhanced significantly as compared with control group. But after injection of GS into abdominal cavity with the same dose, no significant change of splenocyte proliferation to ConA was found. Be-sides , our data also indicated that GS, injected into HC, could promote NK cell activity, increase proliferative response of spleen B lymphocytes to SAC bacteria, enhance IL -2 production and IL -2R expression of spleen T lymphocytes. The study showed that GS could promote indirectly the immunce function of spleno-cytes via HC.
