HISTOCHEMICAL OBSERVATION OF CARBOHYDRATE RESIDUES BY USE OF LECTINS IN PRECANCEROUS LESIONS ADJACENT TO EARLY GASTRIC CARCINOMA
- VernacularTitle:早期胃癌旁癌前病变糖基的组织化学研究
- Author:
Ning LI
;
Qingfu ZHU
;
Weihua LI
- Publication Type:Journal Article
- Keywords:
Gastric mucosa;
Intestinal metaplasia;
Dysplasia;
Lectin;
Carbohydrate residuess
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Carbohydrate residues marked by five biotinylatedlectins (Con A, DBA, PHA, PNA, WGA) and carcinoembryonic antigen (CEA) in intestinal metaplasia and dysplasia adjacent to early gastric carcinoma (EGC) were studied immunohistochemically using ABC technique. The results were as following.The distribution of carbohydrate residues in intestinal metaplasia and dysplasia was different from normal gastric mucosa. The ratio of positivity for DBA and CEA was significantly higher in mucosa adjacent to gastric carcinoma than that in intestinal metaplasia in chronic gastritis and gastric resection margins. The new classification of intestinal metaplasia based on lectin binding demonstrated that the metaplasia was predominantly metaplasia of colonic (ConA + PNA-) and mixed types (ConA +PNA + ) in Carcinoma free gastric mucosa of either intestinal or diffuse carcionma. Some of the diffuse gastric carcinomas may originate from the intestinal meiaplasia.
