Effect of Soman on the Neuro-muscle Junctional and Extrajunctional Nicotinie Acetylcholine Receptors
- VernacularTitle:梭曼对突触内、外N-乙酰胆碱受体的作用
- Author:
Qingwu MAO
;
Naihou WU
;
Yanping ZHU
;
Xiaofei MIAO
- Publication Type:Journal Article
- Keywords:
soman;
receptors, iicetylcholine;
synapses;
radionuclide imaging rats;
mice
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Autoradiography of nicotinic acetylcholine receptors (N-AChR) with the application of histochemical staining location of cholinesterase was used to observe the effect of soman on junctional and extrajunctional N-AChR. Testing with the diaphragms and extensor digitorum longus muscles of mice and rats, we found that soman mainly increased the number of extrajunctional N-AChR. It did pot alter the number of junctional N-AChR significantly, nor did it have any pronounced effects on the glycoprotein property and isoelectric point (pI) of junctional and extrajunctional N-AChR. The change of extrajunctional N-AChR number caused by soman is similar to the phenomenon of increased extrajunctional N-AChR number and sensitivity resulting from denervation, but the mechanism of action is different from the latter. The increase of N-AChR number is one of the important characteristics of soman poisoning which make it different from other nerve agents. To maintain the metabolic balance of N-AChR may be an important new approach to the treatment of soman poisoning.
