Extraction Technology of Coptis in Shutangluo Capsule
- VernacularTitle:舒唐络胶囊中黄连提取工艺的研究
- Author:
Jing SUN
- Publication Type:Journal Article
- Keywords:
Shutangluo Capsule;
coptis;
berberine hydrochloride;
orthogonal design
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To optimize the preparation procedure of coptis in Shutangluo Capsule.Methods: The orthogonal design(L9(34)) was carried out for the optimum extraction conditions of coptis in Shutangluo Capsule.By determining berberine hydrochloride with HPLC method,the mobile phase of HPLC was CH3CN-0.1%H3PO4-CH3(CH2)10CH2OSO2Na(40:60:0.12g).Results: The best extraction process was as follows: reflux with 6 times of 70% alcohol for two times,every time for 1.5hr.Conclusion: The optimum extraction technology is rational and feasible with high extraction rate of berberine hydrochloride.
