Experimental study of pathological changes and role of oxygen free radical in the pathogenesis of myocardial infarction in rats
- VernacularTitle:大鼠实验性心肌梗塞的病理变化及氧自由基在其发生机制中的作用
- Author:
Qiaonan GUO
;
Yisheng CHEN
- Publication Type:Journal Article
- Keywords:
myocardial infarct/UL;
lipid peroxides;
rats
- From:Journal of Third Military Medical University
1984;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The pathological changes of rayocardial infarction induced by liga-tion of a coronary artery were studied under optical and electron microscopy and with enzymohistochemistry,calcium histochemistry,and determination of serum and myocardium homogenate MDA levels in a period of 2 months.The main findings were characterized by early myocardial necrosis and late repair.The ultrastructural changes occurred earlier and involved almost all the.orga-nells,The late repair was mainly incomplete regeneration with the findings of a few regenerated myocardial cells and an"interjunction-like"structure of fibre-blasts.The products of enzymatic reactions decreased rapidly after ligation,which suggests the disturbance of energy metabolism.MDA level of the myocardial homogenate increased in the first 24 hours after liagtion,which implies that myocardial ischemia actually increases lipid oxidation induced by oxygen free radicals and it might be one of the factors for the irreversibility of ischemic myocardial damage.
