The changes of serum and urine guanidinoacetic acid level after cadmium chloride-induced renal injury in rabbits
- VernacularTitle:镉诱发兔肾损害时血清和尿液中胍基乙酸的变化
- Author:
Shuming ZHAO
;
Junfu HUANG
;
Qianyu LIU
- Publication Type:Journal Article
- Keywords:
cadmium;
kidney/IN;
guanidinoacetic acid;
rabbits
- From:Journal of Third Military Medical University
1984;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Subcutaneous injection of 1.0 mg/kg cadmium chloride in 0.8% solution was given to rabbits weighing 1.7~2.5kg 3 times a week for 10 weeks.An equal volume of normal saline was injected to the rabbits of the control group.Blood specimen from the auricle vein and 24-hour-urine of every rabbit were collected once a week.Ten weeks later the renal cortex of the rabbits WES resected,processed routinely and examined under optical microscopy,The level of guanidinoacetic acid (GAA) of the serum and urine was determined with HPLC.It was found that the serum level of GAA increased after 3 weeks of cadmium administration while urinary excretion of GAA increased slightly in the first week and decreased significantly in the second week of cadmium injection and thereafter.
