Study on the significance of prostacyclin and thromboxane in the pathogenesis of ischemic renal injury in rabbits
- VernacularTitle:前列环素、血栓素在缺血性肾损害中的作用
- Author:
Zehou WANG
;
Bin HE
;
Huagcn MO
- Publication Type:Journal Article
- Keywords:
prostaglandins X;
thromboxane A2;
kidney/IN
- From:Journal of Third Military Medical University
1984;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
In order to investigate the significance of prostacyclin and throm-boxere A2 in the pathegertsis of ischemic renal injury,the level of 6-keto-PGF1? and TXB2 in the plasma and the dissected slices of the kidneys of the rabbits with iscbemic renal injury was determined with RIA,It was found that 6-keto-PGF1? increased significantly in the outer and inner medullae,TXB2 increased significantly in all the renal slices,and the 6-keto-PGF1?/TXB2 ratio decreased significantly in the outer cortex 3 hours after reperfusion,The findings suggest that the imbalance between the synthesis of prostacyclin and thromboxane A2 might be resporsible for the decline and redistribution of renal blood flow in the early stage of acute ischemic renal failure.
