Effects of acute cyanide intoxication on brain monoamine transmitters in the rat
- VernacularTitle:氰化物对大鼠脑单胺类递质的影响
- Author:
Yong LIU
;
Xiangde WEI
- Publication Type:Journal Article
- Keywords:
cyanide/TO;
brain;
dopamine;
norepinephrine;
serotonin;
rats
- From:Journal of Third Military Medical University
1984;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of acute cyanide intoxication on the monoamine transmitters of the brain of the rats were observed.The level of dopamine (DA),norepinephrine(NE),serotonin (5-HT),and 5-hydroxyindoleacetic acid (5-HIAA) in the rat brain was measured 3,5,10,30,45 and 60 minutes after the animals were poisoned with intraperitoneal injection of NaCN.It was found that the level of the 4 monoamine transmitters was doseage-dependentty decreased and a lower dosage of 2.36 mg/kg of NaCN increased the level of DA and NE at the 45th minute after intoxication.It was also found that cyanide-induced convulsions were accompanied with a significant decrease of brain monoamine transmitters.It is believed that the changes of the level of mona-mine transmitters in the brain may play a role in the central intoxication of cyanide.
