PROTECTIVE EFFECT OF PHENCYCLIDINE ON ACUTE CEREBRAL ISCHEMIA OF RABBIT-ANALYSIS OF BETA- ENDORPHIN IMMUNOREACTIVITY IN CEREBROSPINAL FLUID
- VernacularTitle:苯环利定对兔急性脑缺血损伤的保护作用——脑脊液中?-内啡肽免疫活性分析
- Author:
Yifeng LU
;
Anzhong ZHANG
- Publication Type:Journal Article
- Keywords:
Phencyclidine;
Beta-Endorphin;
Cerebral ischemia;
Cerebrospinal fluid;
Rabbits
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Acute cerebral ischemia and reperfusion injury of rabbits was produced by permanently occluding the vertebral arteries and temporarily clamping the common carotid arteries for 30 min. Beta-endorphin immunoreactive substance ( ir beta-endorphin ) content were measured in cerebrospinal fluid at pre-ischemia and after ischemia and reperfusion stages. In control group, the content of ir beta-endorphin significantly increased (1.01?0.52 mg/L, P
